leukaemia diagnosis

barbara jane bain


from the bestselling author, barbara j. bain, the new edition of this practical reference on the principles of leukaemia diagnosis and classification has been fully updated, and incorporates the recently revised who classification. leukaemias are a very heterogeneous group of diseases, which differ from each other in aetiology, pathogenesis, prognosis and responsiveness to treatment. accurate diagnosis and classification are vital for the identification of specific biological entities and underpin scientific advances in this field. the detailed characterization of haematological neoplasms is also essential for the optimal management of individual patients. in this user-friendly guide, professor bain illustrates and explains how these many laboratory techniques are used for the diagnosis and classification of leukaemia and related disorders. leukaemia diagnosis, fifth edition will be highly valuable to trainee haematologists and laboratory scientists in haematology and related disciplines, and will also prove a useful reference source and teaching aid for those who already have expertise in this field.
in addition, cytogeneticists and molecular geneticists will find that this book enhances their understanding of the relationship of their disciplines to the diagnosis, classification and monitoring of leukaemia and related disorders. essential reading for every haematologist and haematopathologist, leukaemia diagnosis, fifth edition features * over 300 high quality full colour digital images of abnormal cells in leukaemia and lymphoma supplemented by histological, cytogenetic and immunophenotyping images * recent information on cytogenetic and molecular genetic abnormalities in leukaemia * updated information on the characteristic immunophenotypic characteristics of different categories of leukaemiashow more

practical transfusion medicine

michael f. murphy


the fifth edition of this practical textbook on transfusion medicine has been thoroughly revised with the latest in scientific and technological developments and edited by a leading team of international expert haematologists, including new co-editor mark h. yazer md. * a succinct and user-friendly resource of transfusion medicine for clinicians, scientists and trainees with key points, charts and algorithms * discusses practice in blood centres and hospitals including regulatory aspects, transfusion safety, production and storage, donor care, and blood transfusion in a global context * coverage of cellular and tissue therapies and organ transplantation including stem cell collection and haematopoietic stem cell processing and storage * review of the development of the evidence-base for transfusion medicine * content on the clinical practice for transfusion and alternatives to transfusionshow more

managing myeloproliferative neoplasms a case based approach

ruben a. mesa


this is a concise, practical, case-based book documenting examples and scenarios that will help you manage challenging clinical issues for patients with myeloproliferative neoplasms. the editors and authors have strived to distil the very latest information in this rapidly advancing field in a way that will help you to update your practice and manage your patients. the key focuses are: diagnosis, both standard and challenging; both day-to-day management as well as special situations such as surgery, thrombotic events and pregnancy; and finally, managing evolving situations with mpn such as progression to acute myeloid leukemia. this book is an outstanding resource that includes a discussion of both classical myeloproliferative neoplasms, such as essential thrombocythemia, polycythemia vera and myelofibrosis, and also less common disorders such as systemic mast cell disease, hypereosinophilia, mpn/mbs overlap syndromes and atypical cml, amongst others. this book is a practical reference for practitioners, hematologists, medical oncologists and trainees.show more

congenital and acquired bone marrow failure

eliane gluckman


congenital and acquired bone marrow failure is a comprehensive guide to congenital and acquired bone marrow failure in adult and pediatric patients. chapters are divided into two sections, acquired aplastic anemia and inherited bone marrow failure syndromes. content ranges from the basic, to the translational, and from the epidemiology of acquired aplastic anemia and telomere biology, to the management, treatment, and supportive care of pediatric, adult, and geriatric patients. contributors are world leading experts in the field of bone marrow failure. the book is required reading for residents, fellows, clinicians, and researchers across hematology, oncology, pathology, bone marrow transplantation, pediatrics, and internal medicine.show more

paroxysmal nocturnal hemoglobinuria from bench to bedside

yuzuru kanakura


this volume reviews the fundamental understanding of this potentially life-threatening disease and the advances in treatment that have been achieved with the use of the monoclonal antibody eculizumab. although the piga gene has been known for many years, the mechanism of clonal dominance in paroxysmal nocturnal hemoglobinuria is still largely unknown. this book, paroxysmal nocturnal hemoglobinuria, discusses the direction of continuing research in this area, as well as the potential for the development of management guidelines. it serves as a valuable source of information for both basic scientists and physicians, especially immunologists targeting gpi-anchored proteins and complements, and hematologists specializing in bone marrow failure.show more

clinical hematology theory procedures

mary lou turgeon


designed to help students develop the professional entry-level competencies they need for certification and career success, this 6th edition of clinical hematology strengthens the pedagogy that set the quality benchmark for hematology and includes the current, competency-based content needed by mlt and mls students. in addition to state-of-the-art content, many, fully developed case studies with critical thinking discussion questions, and a strong emphasis on emerging molecular diagnostics and genomic medicine, the 6th edition encompasses the professional knowledge guidelines recommended by ascls entry level and professional body of knowledge competencies in hematology, hemostasis and coagulation, and molecular applications. throughout the text, a logical eight-part organization, clear explanations, and multiple learning tools help students master the theory underlying clinical hematology and the procedures used to diagnose and treat disorders of the blood and bone marrow.expanded coverage of next generation sequencing (ngs) in the molecular techniques chapter reflects the importance of molecular diagnostics and genomic medicine in today's medical laboratories.numerous clinical case studies with critical thinking group discussion questions link concepts and procedures to laboratory practice.two dedicated chapters provide step-by-step procedure instructions, enabling students to confidently perform important clinical procedures.learning outcomes and review questions now identified as core and advanced content clarify what mlt and mls students should know upon successful completion of each chapter.more algorithms and other student desired visual learning formats (figures, tables and boxes) clarify key points.in-text learning aids (learning outcomes, chapter highlights and review questions) organized by major topic to facilitate concept mastery.a streamlined phlebotomy chapter focuses on the newest content with additional information moved online for easy access.bulleted chapter highlights facilitate quick review of each chapter s material.key terms italicized in the text and defined in the glossary help students master the vocabulary of hematology.certification-style review questions help students assess their knowledge as they advance through each chapter.updated full-color images offer a visual guide to the concepts and procedures presented in the text.updated references reflect the latest research in the field."show more

practical hemostasis and thrombosis

nigel s. key


designed as a practical, succinct guide, for quick reference by clinicians with everyday questions, this title guides the reader through the range of approaches available for diagnosis, management, or prevention of hemorrhagic and thrombotic diseases or disorders. * provides essential practical management for all those working in the field of hemostasis and thrombosis * includes new chapters on direct oral anticoagulants, acquired inhibitors of coagulation, and expanded discussion of thrombotic microangiopathies * covers in a clear and succinct format, the diagnosis, treatment and prevention of thrombotic and haemostatic disorders * follows templated chapter formats for rapid referral, including key points and summary boxes, and further reading * highlights controversial issues and provides advice for everyday questions encountered in the clinicshow more

williams manual of hematology

marshall al lichtman


a full-color clinical reference covering both common and uncommon blood disorders – referenced to the world's leading hematology text. williams manual of hematology, ninth edition provides a quick-access summary of the epidemiology, etiology, pathogenesis, diagnostic criteria, differential diagnosis, and therapy of blood cell and coagulation protein disorders. the 93 chapters of the manual are a distillation of the disease – and therapy -focused chapters from the ninth edition of williams hematology. the book has been carefully edited to deliver only the most clinical point-of-care facts, making differential diagnosis faster, easier, and more efficient. concise but comprehensive, this complete guide includes sections on: initial clinical evaluation; disorders of red cells; disorders of granulocytes; disorders of monocytes and macrophages; principles of therapy for neoplastic hematological disorders; the clonal myeloid disorders; the polyclonal lymphoid diseases; the clonal lymphoid and plasma cell diseases; disorders of platelet and hemostasis; disorders of coagulation proteins; thrombosis and antithrombotic therapy; and, transfusion and hemapheresis.show more

waldenstroms macroglobulinemia 2017

veronique leblond


this book sheds new light on clinical, biological and therapeutic data on the rare disease waldenstrom's macroglobulinemia (wm) with the participation of widely-recognized experts, involved in this field. it represents the efforts of physicians, scientists and patients, all around the world, to better understand and cure this rare disease. considerable advances in the diagnosis, treatment indications, response criteria, prognostic factors and treatment options have been made since dr jan waldenstrom first reported this "new syndrome" 70 years ago. particularly instrumental in advancing of our understanding of wm have been the eight international workshops devoted to this disease. new, exciting molecular data have recently been reported, allowing us to revisit the oncogenic events leading to wm b-cell proliferation and to use newly available compounds targeting oncogenic pathways.show more

sickle cell anemia 2016 from basic science to clinical practice

fernando ferreira costa


although sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. a single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of symptoms associated with the disease. our knowledge regarding sickle cell disease mechanisms, while still not complete, has broadened considerably over the last decades. sickle cell anemia: from basic science to clinical practice aims to provide an update on our current understanding of the disease's pathophysiology and use this information as a basis to discuss its manifestations in childhood and adulthood. current therapies and prospects for the development of new approaches for the management of the disease are also covered.show more

radiation therapy in hematologic malignancies 2017 an illustrated practical guide

bouthaina dabaja


this book is designed to assist practitioners in managing patients who present with difficult cases of the most common hematological malignancies. the scenarios covered are those that are likely to be encountered in patients with the various forms of hodgkin's lymphoma, non-hodgkin's lymphoma, and leukemia. in each of the three sections devoted to these malignancies, multiple cases are presented. the case discussions follow a standard format. a clinical description is followed by a pathological description documenting information relevant to diagnosis and by details of staging work-up, including images. the treatment options are then discussed at length, highlighting relevant literature for each option. finally, the treatment delivered is identified and images of the planning technique/modality used are provided. this book will be an invaluable aid to decision making for radiation oncologists and will also be of interest for hematologists.show more

nonmalignant hematology 2016 expert clinical review questions and answers

syed a. abutalib


this book, in q&a format, addresses a wide range of clinically relevant topics and issues in nonmalignant hematology, or "benign hematology," with a view to offering a robust, engaging tool that will assist every hematologist and oncologist (pediatric and adult equally) in making decisions during day-to-day practice. the entire spectrum of the specialty is covered in more than 60 exceptional chapters written by acknowledged authorities in the field. the content is organized into well-designed broad sections on red cell disorders, platelet and coagulation disorders, coagulopathy in systemic diseases, thromboembolic disease and its management (including surgical), immune system and related disorders, hemostasis and thrombosis during pregnancy and in the newborn and elderly, and transfusion medicine. a key aspect of the book is the opportunity it affords expert physicians to express well-reasoned opinions regarding complex issues in nonmalignant hematology. readers will find that it provides a practical and immediately applicable compendium of answers to often complex and vexing questions.
it will appeal to residents, fellows, house officers and more experienced practitioners around the globe.show more

management of bleeding patients 2016

jun teruya


this volume provides a comprehensive and state-of-the-art overview of the major issues specific to managing bleeding patients. the sections of the book have been structured to review the overall scope of issue, among them bleeding conditions, managing bleeding including clearing patients for surgery, and massive bleeding during surgery. reflecting the multidisciplinary care that is an integral part of managing bleeding patients, the book is written by authors from a variety of integrated disciplines, including transfusion medicine, hematology, pediatric hematology, critical care medicine, pediatric critical care medicine, obstetrics, and anesthesia. the volume also includes brief etiology and a practical reference guide regarding type of blood components, medication, dose, and duration. management of bleeding patients is a valuable resource for clinicians working in the area of bleeding management.show more

hematologic abnormalities and acute lung syndromes 2017

janet s. lee


this book provides a unique frame work for examining acute lung syndromes that arise from hematologic disorders or is defined by a hematologic abnormality as a key feature. acute lung processes arising from hematologic disorders can present as life-threatening conditions, and as such, the pulmonary physician or critical care physician are often directly involved in care or called upon to provide expertise. chapters are organized into three sections, each with an emphasis on pathogenesis and current understanding of mechanisms. the text begins with the central theme of the lungs as the direct interface between the external environment and blood, description of individual components of the hematopoietic system, their function and relevance to the lungs. the second section outlines both benign and malignant primary hematologic disorders that can lead to acute pulmonary manifestations. the final section focuses on acute lung syndromes stemming from complications of transfusion and treatment. chapters are presented in an easy-to-access format, providing information on diagnosis, management, and outcomes.
this is a valuable resource for pulmonary fellows in training, pulmonologists, critical care physicians, and physicians involved in caring for patients in the icu.show more

blood and marrow transplant handbook 2015 comprehensive guide for patient care

richard t. maziarz


this updated and expanded edition developed by the blood and marrow stem cell transplant team at oregon health & science university knight cancer institute features the latest medical management guidelines and standards of care for hematopoietic stem cell transplant patients. spanning the timeline from the initial consultation throughout the transplant process, this handbook includes indications for transplantation and donor selection, treatment guidelines for addressing complications during and after transplant, and recommendations for long-term follow up care. concise, comprehensive, and easy-to-use, blood and marrow transplant handbook, 2nd edition presents a multidisciplinary approach to information for physicians and advanced practice medical providers who care for transplant patients, and also residents, fellows, and other trainees.show more

dacie and lewis practical haematology

barbara jane bain


for more than 65 years, this best-selling text by drs. barbara j. bain, imelda bates, and mike a. laffan has been the worldwide standard in laboratory haematology. the 12th edition of dacie and lewis practical haematology continues the tradition of excellence with thorough coverage of all of the techniques used in the investigation of patients with blood disorders, including the latest technologies as well as traditional manual methods of measurement. you'll find expert discussions of the principles of each test, possible causes of error, and the interpretation and clinical significance of the findings.show more

transfusion medicine 4th edition

jeffrey mccullough


transfusion medicine provides a concise, clinically focused and practical approach to the field of blood banking and transfusion therapy written by international expert, jeffrey mccullough md. * concise, approachable, yet comprehensive approach to the field of transfusion medicine and blood banking * offers extensive guidance on important topics such as; donor recruitment, blood collection and storage, donor testing and clinical uses of blood components, techniques of administration of blood components, complications of transfusion, transmissible diseases, the hla system, and many more * provides new content on patient blood management systems, the changing indications for red cell transfusion, new transmissible disease agents, management of massive blood loss, pathogen reduced blood components, therapeutic apheresis including photopheresis, management of massive transfusion and new cellular therapies.
* discusses global blood supply and us blood supply organizations and their consolidation and reorganization * reviews other topics of current interest, such as mitigation strategies for trali prevention, effects of storage of blood on adverse effects, management of massive blood loss and massive transfusion protocols pathogen inactivation, and granulocyte transfusion * extensively referenced for further studyshow more

harrisons hematology and oncology

dan l. longo


hematology and oncology – backed by the unmatched authority of harrison's featuring a superb compilation of chapters related to hematology and oncology derived from harrison's principles of internal medicine, nineteenth edition (including content from the acclaimed harrison's dvd, now available here in print), this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined harrison's. you will find 57 chapters from more than 75 renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation. features: * each chapter contains relevant information on the genetics, cell biology, pathophysiology, and treatment of specific disease entities * chapters on hematopoiesis, cancer cell biology, and cancer prevention reflect the rapidly growing knowledge in these areas * integration of pathophysiology with clinical management * high-yield board review questions make this text ideal for keeping current or preparing for the boards * valuable appendix of laboratory values of clinical importanceshow more

hiv associated hematological malignancies 2016

marcus hentrich

this book presents a general introduction to and review of hiv-associated hematological malignancies, with a special focus on practical management issues. each of the relevant malignancies is addressed individually, with an overview of treatment approaches, assessment of evidence regarding their efficacy, and discussion of therapeutic controversies. in addition, careful consideration is paid to issues in molecular and clinical pathology, epidemiological aspects, symptomatology, diagnosis, and risk factors. separate chapters are devoted to autologous and allogeneic stem cell transplantation and to chemotherapy and interactions with antiretroviral agents. many of the chapters are written by experts who have been instrumental in shifting the balance for people living with hiv and blood cancers. while two decades ago this diagnosis represented a death sentence, advances in treatment have transformed these cancers into often curable conditions. nevertheless, optimal treatment of hematological malignancies remains a challenge, particularly in patients with severe immunosuppression.
this book will be an invaluable source of information for all practitioners in the fields of clinical hematology and medical oncology and hiv medicine.

the genetic basis of haematological cancers

sabrina tosi, alistair g. reid

written by a team of international experts, this book provides an authoritative overview and practical guide to the molecular biology and genetic basis of haematologic cancers including leukemia. focusing on the importance of cytogenetics and related assays, both as diagnostic tools and as a basis for translational research, this is an invaluable guide for basic and clinical researchers with an interest in medical genetics and haemato-oncology.

the genetic basis of haematological cancers reviews the etiology and significance of genetic and epigenetic defects that occur in malignancies of the haematopoietic system. some of these chromosomal and molecular aberrations are well established and already embedded in clinical management, while many others have only recently come to light as a result of advances in genomic technology and functional investigation. the book includes seven chapters written by clinical and academic leaders in the field, organised according to haematological malignancy sub-type. each chapter includes a background on disease pathology and the genetic abnormalities most commonly associated with the condition. authors present in-depth discussions outlining the biological significance of these lesions in pathogenesis and progression, and their use in diagnosis and monitoring response to therapy. the current or potential role of specific abnormalities as novel therapeutic targets is also discussed. there is also a full colour section containing original fish, microarrays and immunostaining images. 

rodaks hematology clinical principles and applications 5th edition

ph.d. elaine m. keohane; ph.d. larry j. smith; ph.d. jeanine m. walenga

featuring hundreds of full-color photomicrographs, rodak’s hematology: clinical principles and applications, 5th edition prepares you for a job in the clinical lab by exploring the essential aspects of hematology. it shows how to accurately identify cells, simplifies hemostasis and thrombosis concepts, and covers normal hematopoiesis through diseases of erythroid, myeloid, lymphoid, and megakaryocytic origins. this text also makes it easy to understand complementary testing areas such as flow cytometry, cytogenetics, and molecular diagnostics. clinical lab experts elaine keohane, larry smith, and jeanine walenga also cover key topics such as working in a hematology lab, the parts and functions of the cell, and laboratory testing of blood cells and body fluid cells.

williams hematology 9th edition retail pdf

m.d. kenneth kaushansky; m.d. marshall a. lichtman; m.d. josef t. prchal; m.d. marcel levi, ph.d.

“the world’s most highly regarded reference text on the mechanisms and clinical management of blood diseases”

edition after edition, “williams hematology” has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. it is acknowledged worldwide as the leading hematology resource, with editors who are internationally regarded for their research and clinical achievements and authors who are luminaries in their fields.

the ninth edition of “williams hematology” is extensively revised to reflect the latest advancements in basic science, translational pathophysiology, and clinical practice. in addition to completely new chapters, it features a full-color presentation that includes 700 photographs, 300 of which are new to this edition, and 475 illustrations. recognizing that blood and marrow cell morphology is at the heart of diagnostic hematology, informative color images of the relevant disease topics are conveniently integrated into each chapter, allowing easy access to illustrations of cell morphology important to diagnosis.

comprehensive in its depth and breath, this go-to textbook begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.

medical and surgical complications of sickle cell anemia

al-salem, ahmed

this book is a wide-ranging guide to the diagnosis and management of the numerous medical and surgical complications that may arise in patients with sickle cell anemia. after introductory chapters on the genetics, pathophysiology, clinical features, and variants of sickle cell anemia, the complications observed in different parts of the body are addressed in a series of well-illustrated chapters. the coverage includes splenic, hepatobiliary, musculoskeletal, gastrointestinal, ophthalmological, cardio- and cerebrovascular, and renal complications, as well as acute chest syndrome, leg ulcers, hand and foot syndrome, acute appendicitis, and priapism. treatment-oriented chapters consider perioperative management, blood transfusion therapy, hydroxyurea treatment, hematopoietic stem cell transplantation, and emerging strategies. the book is clearly written in a distinctive bullet point format for ease of reference and emphasizes especially aspects of practical significance. it will be of value for hematologists, general surgeons, internists, pediatricians, pediatric surgeons, fellows, residents, medical students, and nurses.

immunohematology and transfusion medicine a case study approach

friedman, mark t, west, kamille a, bizargity, peyman

this volume is a collection of immunohematology and transfusion medicine cases, comprised of clinical vignettes and antibody panels with questions based on each case, arranged in a workbook format. the cases are based on real patient problems which are typically encountered and covers a number of common issues and challenging problems in blood banking and transfusion practice. discussion and resolution of each case is provided in a separate answer section, including up-to-date information on pertinent advances in the field.

written by experts in the field, immunohematology and transfusion medicine: a case study approach provides an interactive tool to help make blood banking and transfusion medicine memorable, practical, and relevant to residents and fellows.

postgraduate haematology 7th edition

victor hoffbrand
postgraduate haematology provides up-to-date knowledge of the pathogenesis, clinical and laboratory features, management and treatment of a wide range of blood and bone marrow disorders in a concise and user friendly style. * up-to-date knowledge of the pathogenesis, clinical and laboratory features and management of all blood disorders * new sections reflect advances in the specialty, including knowledge gained from new generation sequencing, latest anticoagulant drugs, diagnostic laboratory tools, and treatment strategies * superb four-color illustrations and photomicrographs of blood cells and tissues throughout * includes algorithms to aid with decision-making for treatment * companion website includes figures and tables for